In summary, these therapeutic implications of drugs on AIDs ( Table 2 ), are designed to optimize the hypoxic microenvironment through multifaceted pathways, ultimately curbing inflammation and mitigating tissue damage, thereby achieving the desired therapeutic outcomes for autoimmune diseases
Polyphenols, which are plant-based antioxidants that help protect cells from damage and may have some anti-inflammatory benefits
Past research has highlighted the medicinal properties of durian fruit pulp extract, including its antiproliferative effects on various human cancer cell lines 30,31,32,33,34 , neuroprotective effect on the human neuroblastoma cell line SH-SY5Y 35 , and antidiabetic effect on the HepG2 cell line by regulating glycolysis regulatory genes 32
Across all 19 drugs, measured against a standard scale of energy, pain, day-to-day function and mood, no drug produced a change large enough to count as a meaningful improvement at one year not tirzepatide, not semaglutide, not any of the rest
